INCREASED NON-PROTEIN-BOUND IRON AND DECREASED PROTECTION AGAINST SUPEROXIDE-RADICAL DAMAGE IN CEREBROSPINAL FLUID FROM PATIENTS WITH NEURONAL CEROID LIPOFUSCINOSES

Abstract

Cerebrospinal fluid from patients with neuronal ceroid lipofuscinoses (infantile or Santavuori-Haltia type and juvenile type or Batten's disease) has a higher concentration of non-protein-bound iron and lower antioxidant activity than that of controls. These changes may contribute to the pathology of the disorders.