Characterization of T-Cell Lymphomas by FDG PET/CT
- 1 August 2010
- journal article
- Published by American Roentgen Ray Society in American Journal of Roentgenology
- Vol. 195 (2), 333-340
- https://doi.org/10.2214/ajr.09.3665
Abstract
OBJECTIVE. The purpose of this article is to describe the utility of FDG PET/CT in documenting sites of disease in patients with T-cell lymphomas, to quantify the degree of FDG avidity in the various subtypes of this heterogeneous group of disorders, and to highlight the pattern of imaging findings associated with specific disease subtypes. MATERIALS AND METHODS. A retrospective review of patients with T-cell lymphomas who underwent PET/CT examination for initial disease staging or at disease relapse over a 5-year period was undertaken by correlation between a patient database and a PACS radiology information system. Disease subtypes were grouped according to World Health Organization categorization of mature natural killer cell–T-cell neoplasms. Sites of disease involvement were documented according to cutaneous or extranodal, nodal, and visceral locations. The maximum standardized uptake value (SUV) was recorded for each patient. RESULTS. One hundred thirty-five patients with T-cell lymphoma were included, and sites of disease were documented by use of FDG PET/CT in 122 (90%) patients. Of those 122 patients, 55 (45%) had cutaneous involvement, 95 (78%) had FDG-avid lymphadenopathy, and 54 (44%) had FDG-avid extranodal disease other than cutaneous involvement. A significant difference in maximum SUV was observed in cases of mycosis fungoides and mycosis fungoides with large cell transformation (SUV, 11.3 vs 3.8; p < 0.05). CONCLUSION. We found high rates of FDG positivity in T-cell lymphoma. Given the propensity for disease involvement outside the normal scan range of diagnostic CT, we recommend that patients with T-cell lymphoma be scanned from vertex to feet by use of PET/CT.Keywords
This publication has 27 references indexed in Scilit:
- F-18 FDG Uptake in Subcutaneous Panniculitis-Like T-Cell LymphomaClinical Nuclear Medicine, 2008
- F-18 FDG-PET Imaging in Adult T-Cell Leukemia LymphomaClinical Nuclear Medicine, 2008
- Peripheral T-cell LymphomasBlood Reviews, 2007
- FDG-PET Imaging in Cutaneous Anaplastic Large Cell LymphomaClinical Nuclear Medicine, 2006
- Towards understanding the peripheral T-cell lymphomasAnnals of Oncology, 2004
- Peripheral T-Cell Lymphoma: Spectrum of Imaging Findings with Clinical and Pathologic FeaturesRadioGraphics, 2003
- Assessment of tumor burden and treatment response by 18F-fluorodeoxyglucose injection and positron emission tomography in patients with cutaneous T- and B-cell lymphomasJournal of the American Academy of Dermatology, 2002
- Peripheral T-cell lymphoma (excluding anaplastic large-cell lymphoma): results from the Non-Hodgkin’s Lymphoma Classification ProjectAnnals of Oncology, 2002
- A Clinical Evaluation of the International Lymphoma Study Group Classification of Non-Hodgkin's LymphomaBlood, 1997
- The radiological features of adult T-cell leukaemia/lymphomaClinical Radiology, 1994