Pressure-volume relation around zero transmural pressure in excised cross-circulated dog left ventricle.
- 1 August 1988
- journal article
- abstracts
- Published by Ovid Technologies (Wolters Kluwer Health) in Circulation Research
- Vol. 63 (2), 361-372
- https://doi.org/10.1161/01.res.63.2.361
Abstract
Left ventricular (LV) pressure-volume (PV) relations of quasi-isobaric contractions around zero transmural pressure were studied with a new volumetric method. Left ventricles of isolated cross-circulated dog hearts were connected to a large air tank through the mitral annulus. The volume of the air space was changed with a volume servo pump to oscillate the transmural pressure (P) around zero. Instantaneous LV volume (V) was computed from P by Boyle's law (P.V = constant) to draw the PV trajectories of the isobaric contractions. The end-systolic PV relation (ESPVR) and end-diastolic PV relation (EDPVR) curves intercepted the volume axis at two different volumes (Vo and Vu, respectively). The slopes of both ESPVR and EDPVR curves as well as Vo and Vu were variably influenced by positive and negative inotropic states, heart rate changes, arrhythmias, ischemia, and rigor. In control before any interventions, LV stroke and suction volume (delta V = Vu - Vo) at zero P was 7.5 +/- 2.5 (SD) ml/100 g left ventricle, which changed with the changes in Vo and Vu. delta V decreased with decreases in P from zero and virtually vanished at a pressure (Pn) of -9.5 +/- 2.0 mm Hg. Directly measured LV dead volume (Vd) at Pn was 4.1 +/- 1.3 ml/100 g. The results seem essential for evaluation of LV filling and suction during diastole.Keywords
This publication has 12 references indexed in Scilit:
- Intact chordae tendineae increase ventricular volume measurement error by the balloon method.Japanese Heart Journal, 1987
- Effects of coronary arterial pressure on left ventricular end-systolic pressure-volume relation of isolated canine heart.Circulation Research, 1982
- Left ventricular diastolic suction as a mechanism of ventricular filling.Japanese Circulation Journal, 1982
- Mitral Valve Ring in Normal vs Dilated Left VentricleSocial psychiatry. Sozialpsychiatrie. Psychiatrie sociale, 1981
- Restoring forces and relaxation of rat cardiac muscleEuropean Heart Journal, 1980
- Are restoring forces important to relaxation?European Heart Journal, 1980
- The structural basis and importance of restoring forces and elastic recoil for the filling of the heartEuropean Heart Journal, 1980
- Elastic and contractile properties of muscleJournal of Applied Physics, 1976
- Mechanics of ventricular diastoleCardiovascular Research, 1970