Effect of bariatric surgery on circulating chemerin levels
- 26 February 2010
- journal article
- Published by Wiley in European Journal of Clinical Investigation
- Vol. 40 (3), 277-280
- https://doi.org/10.1111/j.1365-2362.2010.02255.x
Abstract
Subclinical inflammation in obesity is critical for development of several obesity-associated disorders. We set out to investigate the effect of pronounced weight loss on circulating chemerin levels, a chemoattractant protein that also influences adipose cell function by paracrine and autocrine mechanisms. Thirty-two obese patients undergoing bariatric surgery were tested before and on an average of 18 months after gastric banding or gastric bypass surgery. Pronounced weight loss after bariatric surgery was accompanied by improvements in parameters of lipid and glucose metabolism and increased adiponectin levels. Chemoattractant chemerin significantly decreased from 175.91 +/- 24.50 to 145.53 +/- 26.44 ng mL(-1) after bariatric surgery (P < or = 0.01). Concomitantly, hs-CRP as a marker of subclinical inflammation was significantly reduced after weight reduction (P < or = 0.01). We hypothesize that weight-loss induced reduction in circulating chemerin might in conjunction with other factors be associated with diminished recruitment of macrophages in adipose tissue and reduction of subclinical inflammation, which again could partly explain beneficial long-term effects of weight reduction in obese subjects.Keywords
This publication has 12 references indexed in Scilit:
- Insulin and Metformin Regulate Circulating and Adipose Tissue ChemerinDiabetes, 2009
- Mechanisms of macrophage activation in obesity-induced insulin resistanceNature Clinical Practice Endocrinology & Metabolism, 2008
- Chemerin Is a Novel Adipokine Associated with Obesity and Metabolic SyndromeEndocrinology, 2007
- Chemerin, a Novel Adipokine That Regulates Adipogenesis and Adipocyte MetabolismJournal of Biological Chemistry, 2007
- Effects of Bariatric Surgery on Mortality in Swedish Obese SubjectsNew England Journal of Medicine, 2007
- Effects of Pronounced Weight Loss on Adiponectin Oligomer Composition and Metabolic ParametersObesity, 2007
- Inflammation and metabolic disordersNature, 2006
- Chemerin Activation by Serine Proteases of the Coagulation, Fibrinolytic, and Inflammatory CascadesPublished by Elsevier BV ,2005
- Specific Recruitment of Antigen-presenting Cells by Chemerin, a Novel Processed Ligand from Human Inflammatory FluidsThe Journal of Experimental Medicine, 2003
- Homeostasis model assessment: insulin resistance and ?-cell function from fasting plasma glucose and insulin concentrations in manDiabetologia, 1985