Novel birch pollen specific immunotherapy formulation based on contiguous overlapping peptides
Open Access
- 1 January 2013
- journal article
- Published by Wiley in Clinical and Translational Allergy
- Vol. 3 (1), 17
- https://doi.org/10.1186/2045-7022-3-17
Abstract
Synthetic contiguous overlapping peptides (COPs) may represent an alternative to allergen extracts or recombinant allergens for allergen specific immunotherapy. In combination, COPs encompass the entire allergen sequence, providing all potential T cell epitopes, while preventing IgE conformational epitopes of the native allergen.Keywords
Funding Information
- Crystal Technology & Industries
This publication has 53 references indexed in Scilit:
- Molecular diagnosis of fruit and vegetable allergyCurrent Opinion in Allergy and Clinical Immunology, 2011
- Ultrashort-specific immunotherapy successfully treats seasonal allergic rhinoconjunctivitis to grass pollenAllergy and Asthma Proceedings, 2011
- Mouse and human neutrophils induce anaphylaxisJCI Insight, 2011
- Clinical effects of immunotherapy with genetically modified recombinant birch pollen Bet v 1 derivativesClinical and Experimental Allergy, 2008
- The impact of pollen‐related food allergens on pollen allergyAllergy, 2006
- Allergen-specific immunotherapy with recombinant grass pollen allergensJournal of Allergy and Clinical Immunology, 2005
- Bet v 1142-156 is the dominant T-cell epitope of the major birch pollen allergen and important for cross-reactivity with Bet v 1–related food allergensJournal of Allergy and Clinical Immunology, 2005
- Mutants of the major ryegrass pollen allergen, Lol p 5, with reduced IgE-binding capacity: candidates for grass pollen-specific immunotherapyEuropean Journal of Immunology, 2002
- Three-Dimensional Structure and Epitopes of Bet v 1International Archives of Allergy and Immunology, 1997
- Structural consequences of sequence patterns in the fingerprint region of the nucleotide binding fold: Implications for nucleotide specificityJournal of Molecular Biology, 1992