Association of Low Vitamin D Levels With the Frailty Syndrome in Men and Women
Open Access
- 1 January 2009
- journal article
- research article
- Published by Oxford University Press (OUP) in The Journals of Gerontology: Series A
- Vol. 64A (1), 69-75
- https://doi.org/10.1093/gerona/gln007
Abstract
Although both vitamin D (25-hydroxyvitamin D [25(OH)D]) insufficiency and the frailty syndrome are more prevalent in women than men, sex-specific associations have not been explored. We estimated sex-specific associations of low 25(OH)D with frailty. Vitamin D insufficiency can result in hyperparathyroidism, and thus, parathyroid hormone (PTH) was explored as a potential mediator in the relationship between 25(OH)D levels and frailty. The sample included 444 male and 561 female participants aged 65 years and older from the InCHIANTI study for whom 25(OH)D levels and frailty information were available. Frailty was defined as the presence of at least three of the five following criteria: slowness, weakness, low energy expenditure, exhaustion, and weight loss. Logistic regression models estimated the association between serum levels of 25(OH)D and PTH with frailty, controlling for potential confounders. Independent of covariates, men with 25(OH)D p = .041). ORs changed little after controlling for PTH. However, when low energy expenditure was excluded from the frailty definition, adjusted OR for frailty in men (95% CI) was 2.18 (0.59–8.04); controlling for PTH attenuated this OR by 32%. In women, the OR (95% CI) for frailty (low energy expenditure excluded) was 1.54 (0.31–7.58) and was attenuated by 6% after controlling for PTH. Vitamin D insufficiency was associated with frailty in men, but not in women. Results suggest that PTH mediates the relationship between 25(OH)D and nonenergy expenditure aspects of frailty.Keywords
This publication has 42 references indexed in Scilit:
- Vitamin D physiologyProgress in Biophysics and Molecular Biology, 2006
- Endocrine and inflammatory markers as predictors of frailtyClinical Endocrinology, 2005
- Vitamin D and calcium deficits predispose for multiple chronic diseasesEuropean Journal of Clinical Investigation, 2005
- Sex Differences in the Risk of Frailty for Mortality Independent of Disability and Chronic DiseasesJournal of the American Geriatrics Society, 2004
- Hypovitaminosis D-induced PainNutrition Reviews, 2004
- Vitamin D Deficiency and Secondary Hyperparathyroidism in the Elderly: Consequences for Bone Loss and Fractures and Therapeutic ImplicationsEndocrine Reviews, 2001
- Relative validity and reproducibility of a food frequency dietary questionnaire for use in the Italian EPIC centresInternational Journal of Epidemiology, 1997
- Avian muscle cells as targets for the secosteroid hormone 1,25-dihydroxy-vitamin D3Molecular and Cellular Endocrinology, 1995
- Vitamin D Deficiency, hypocalcemia, and increased skeletal muscle degradation in rats.JCI Insight, 1983
- “Mini-mental state”: A practical method for grading the cognitive state of patients for the clinicianJournal of Psychiatric Research, 1975