A 200‐amino acid ATPase module in search of a basic function
- 1 July 1995
- Vol. 17 (7), 639-650
- https://doi.org/10.1002/bies.950170710
Abstract
A fast growing family of ATPases has recently been highlighted. It was named the AAA family, for ATPases Associated to a variety of cellular Activities. The key feature of the family is a highly conserved module of 230 amino acids present in one or two copies in each protein. Despite extensive sequence conservation, the members of the family fulfil a large diversity of cellular functions: cell cycle regulation, gene expression in yeast and HIV, vesicle‐mediated transport, peroxisome assembly, 26S protease function etc. In addition, several members of this family can be found in the same organism (up to 17 in S. cerevisiae). The contrast between functional diversity and structural conservation of the module, from archaebacteria to mammals, suggests that it plays an essential, but as yet unknown, role at key points of the cellular machinery. Two (non‐exclusive) such possibilities are: (1) ATP‐dependent proteasome function and (2) ATP‐dependent anchorage of proteins. Finally, the basic biochemical activity of the AAA module is still a matter of speculation, and we propose that it acts as an ATP‐dependent protein clamp.This publication has 76 references indexed in Scilit:
- Role of the PAS1 gene of Pichia pastoris in peroxisome biogenesis.The Journal of cell biology, 1994
- Yta10p is required for the ATP‐dependent degradation of polypeptides in the inner membrane of mitochondriaFEBS Letters, 1994
- Yta10p, a member of a novel ATPase family in yeast, is essential for mitochondrial functionFEBS Letters, 1994
- SAV, an archaebacterial gene with extensive homology to a family of highly conserved eukaryotic ATPasesJournal of Molecular Biology, 1994
- Cloning and characterization of PAS5: a gene required for peroxisome biogenesis in the methylotrophic yeast Pichia pastoris.The Journal of cell biology, 1993
- Molecular Cloning and Developmental Regulation of Dictyostelium discoideum Homologues of the Human and Yeast HIV1 Tat-Binding ProteinBiochemical and Biophysical Research Communications, 1993
- SNAP receptors implicated in vesicle targeting and fusionNature, 1993
- Ubiquitous soluble Mg2+-ATPase complex: A structural studyJournal of Molecular Biology, 1992
- Basic local alignment search toolJournal of Molecular Biology, 1990
- SNAPs, a family of NSF attachment proteins involved in intracellular membrane fusion in animals and yeastCell, 1990