Hemostatic Factors as Predictors of Ischemic Heart Disease and Stroke in the Edinburgh Artery Study
- 1 November 1997
- journal article
- research article
- Published by Ovid Technologies (Wolters Kluwer Health) in Arteriosclerosis, Thrombosis, and Vascular Biology
- Vol. 17 (11), 3321-3325
- https://doi.org/10.1161/01.atv.17.11.3321
Abstract
Plasma fibrinogen is a consistent predictor of ischemic heart disease (IHD) in prospective studies, but there are fewer data relating other hemostatic variables to IHD and also to stroke. We therefore studied the relationships of plasma fibrinogen, von Willebrand factor antigen, tissue plasminogen activator (TPA) antigen, factor VII, and fibrin D-dimer to incidence of IHD and stroke and determined whether any associations could be explained by conventional risk factors and baseline heart disease. In the Edinburgh Artery study, 1592 men and women aged 55 to 74 years, randomly sampled from the general population, were followed prospectively over 5 years to detect fatal and nonfatal IHD and stroke events. During the 5 years, 268 new vascular events were identified. Baseline plasma fibrinogen was independently related to risk of stroke in multivariate analysis that adjusted for cigarette smoking, LDL-cholesterol, systolic blood pressure, and preexisting IHD (relative risk [RR] 1.52, 95% confidence interval [CI] 1.17,1.98). TPA antigen, and fibrin D-dimer were also independently associated with risk of stroke (RR 1.69, 95% CI 1.22,2.35 and RR 1.96, 95% CI 1.12,3.41, respectively). Significant relationships were found between TPA antigen and myocardial infarction (P≤.05). In older men and women, increased coagulation activity and disturbed fibrinolysis are predictors of future vascular events (both IHD and stroke).Keywords
This publication has 21 references indexed in Scilit:
- Blood viscosity and risk of cardiovascular events: the Edinburgh Artery StudyBritish Journal of Haematology, 1997
- Incidence, Natural History and Cardiovascular Events in Symptomatic and Asymptomatic Peripheral Arterial Disease in the General PopulationInternational Journal of Epidemiology, 1996
- Increased markers of thrombogenesis in chronic atrial fibrillation: effects of warfarin treatment.Heart, 1995
- Prospective study of endogenous tissue plasminogen activator and risk of strokeThe Lancet, 1994
- Endogenous tissue-type plasminogen activator and risk of myocardial infarctionThe Lancet, 1993
- Fibrinogen and lipid concentrations as risk factors for transient ischaemic attacks and minor ischaemic strokes.BMJ, 1991
- Fate of fibrinogen in human arterial intima.Arteriosclerosis: An Official Journal of the American Heart Association, Inc., 1990
- HAEMOSTATIC FUNCTION AND ISCHAEMIC HEART DISEASE: PRINCIPAL RESULTS OF THE NORTHWICK PARK HEART STUDYThe Lancet, 1986
- Fibrinogen as a Risk Factor for Stroke and Myocardial InfarctionNew England Journal of Medicine, 1984
- International diagnostic criteria for acute myocardial infarction and acute strokeAmerican Heart Journal, 1984