Hepatoprotective activity of brown alga Padina boergesenii against CCl4 induced oxidative damage in Wistar rats
Open Access
- 1 September 2010
- journal article
- Published by Medknow in Asian Pacific Journal of Tropical Medicine
- Vol. 3 (9), 696-701
- https://doi.org/10.1016/s1995-7645(10)60168-x
Abstract
Objective: To investigate the protective effects of brown alga Padina boergesenii (P. boergeseii) against carbon tetrachloride (CCl 4) induced oxidative damage and liver fibrosis in rats. Methods: To assess the hepatic damage liver weight, the activities of TBARS level, glutathione, SOD, CAT and GP x in circulation and liver. Results: The group of rats induced with CCl 4 alone (2 mL/kg body weight), showed noticeable increase in the liver weight and TBARS level. Followed by, the level of antioxidant enzymes glutathione peroxidase, Superoxide dismutase and catalase was also significantly (P P. boergesenii (150 mg/kg body weight) modulated the CCl 4 induced liver fibrosis. The level of antioxidant enzymes and lipid peroxidation products was found to be significantly (P P. boergesenii. Conclusions: The protective role of brown alga P. boergesenii extract has confirmed its potential activity through its antioxidant sparing actions against CCl 4 i nduced free radical damage. However, the possible mechanism of hepatoprotection is rather speculative at this stage and investigations are underway to isolate and characterize the bioactive compounds from P. boergesenii.Keywords
This publication has 15 references indexed in Scilit:
- Chemopreventive effect of Padina boergesenii extracts on ferric nitrilotriacetate (Fe-NTA)-induced oxidative damage in Wistar ratsJournal of Applied Phycology, 2010
- Defensive and Sensory Chemical Ecology of Brown AlgaePublished by Elsevier BV ,2005
- Studies on the protective effects of caffeic acid and quercetin on chemical-induced hepatotoxicity in rodentsPhytomedicine, 2004
- Evaluation of Antioxidative Activity of Extracts from a Brown Seaweed, Sargassum siliquastrumJournal of Agricultural and Food Chemistry, 2002
- Chemopreventive effects of carotenoids and curcumins on mouse colon carcinogenesis after 1,2-dimethylhydrazine initiationCarcinogenesis: Integrative Cancer Research, 1998
- Damage to DNA by reactive oxygen and nitrogen species: role in inflammatory disease and progression to cancerBiochemical Journal, 1996
- Inhibitory effects of fucoxanthin, a natural carotenoid, on N-ethyl-N′-nitro-N-nitrosoguanidine-induced mouse duodenal carcinogenesisCancer Letters, 1993
- Te marine algae of Lord Howe Island (NSW): The dictyotales and Cutleriales (Phaeophyta).Brunonia, 1983
- Colorimetric Determination of dl-α-Tocopherol (Vitamin E)Nature, 1938
- Colorimetric determination of α‐tocopherol (vitamin E)Recueil des Travaux Chimiques des Pays-Bas, 1938