13 years of cultured limbal epithelial cell therapy: A review of the outcomes
- 11 March 2011
- journal article
- review article
- Published by Wiley in Journal of Cellular Biochemistry
- Vol. 112 (4), 993-1002
- https://doi.org/10.1002/jcb.23028
Abstract
The cornea is the clear tissue at the front of the eye which enables the transmission of light to the retina for normal vision. The surface of the cornea is composed of an epithelium which is renewed by stem cells located at the periphery of the cornea, a region known as the limbus. These limbal stem cells can become deficient as a result of various diseases of the eye's surface, resulting in the blinding disease of limbal stem cell deficiency. The treatment of this disease is often difficult and complex. In 1997, it was proposed that a small amount of limbal tissue containing limbal stem cells could be culture expanded and then transplanted. Since then various case reports and case series have been reported showing promising results. Here, we review the outcomes of this procedure over the past 13 years with the aim of highlighting the best culture and surgical techniques to date. J. Cell. Biochem. 112: 993–1002, 2011.Keywords
This publication has 47 references indexed in Scilit:
- Vision from the right stemTrends in Molecular Medicine, 2011
- The culture and transplantation of human limbal stem cellsJournal of Cellular Physiology, 2010
- Evaluation of Molecular Markers in Corneal Regeneration by Means of Autologous Cultures of Limbal Cells and KeratoplastyCornea, 2010
- Stem cell therapies for ocular surface diseaseDrug Discovery Today, 2010
- Quality of Life after Limbal TransplantsOphthalmology, 2010
- Successful Clinical Implementation of Corneal Epithelial Stem Cell Therapy for Treatment of Unilateral Limbal Stem Cell DeficiencyThe International Journal of Cell Cloning, 2009
- Serum eye drops, amniotic membrane and limbal epithelial stem cells—tools in the treatment of ocular surface diseaseCell and Tissue Banking, 2009
- A Comparison Between Cultivated and Conventional Limbal Stem Cell Transplantation for Stevens-Johnson SyndromeAmerican Journal of Ophthalmology, 2007
- Successful primary culture and autologous transplantation of corneal limbal epithelial cells from minimal biopsy for unilateral severe ocular surface diseaseActa Ophthalmologica Scandinavica, 2004
- Use of Autologous Cultured Limbal and Conjunctival Epithelium in a Patient with Severe Bilateral Ocular Surface Disease Induced by Acid InjuryCornea, 2003