Elevated CCR6+ CD4+ T lymphocytes in tissue compared with blood and induction of CCL20 during the asthmatic late response
Open Access
- 16 April 2008
- journal article
- Published by Oxford University Press (OUP) in Clinical and Experimental Immunology
- Vol. 152 (3), 440-447
- https://doi.org/10.1111/j.1365-2249.2008.03657.x
Abstract
CCR6 is expressed by multiple leucocyte subsets, including peripheral blood memory T cells, and mouse models implicate a role for this receptor in diverse inflammatory responses that include allergic airway disorders, inflammatory bowel disease and autoimmune encephalitis. In order to study the role of CCR6 in humans, we have investigated the patterns of CCR6 expression and function on T cells from the peripheral blood, skin, nose and lung, in health and in allergic disease. Results show that CCR6 was expressed consistently on a higher proportion of tissue versus peripheral blood-derived CD4+ T cells (P < 0·01). CCR6 was expressed predominantly on CD4+ compared with CD8+ cells in both blood- and tissue-derived T cells (P < 0·001). The number of cells showing CCR6 expression was not proportionally greater in peripheral blood or nasal mucosal T cells of subjects with symptomatic allergic rhinitis. CCR6+ cells demonstrated enhanced functional responses to CCL20 and CCL20 was increased in bronchoalveolar lavage fluid of asthmatics following endobronchial allergen provocation (P < 0·05). Thus, CCR6 may be important in the regulation of T cell recruitment to tissue and up-regulation of CCL20 expression may contribute to the recruitment and/or retention of effector T cells in allergic asthma.Keywords
This publication has 31 references indexed in Scilit:
- Functional expression of chemokine receptor CCR6 on human effector memory CD8+ T cellsEuropean Journal of Immunology, 2006
- T lymphocytes expressing CCR3 are increased in allergic rhinitis compared with non‐allergic controls and following allergen immunotherapyAllergy, 2006
- CCR6-Mediated Dendritic Cell Activation of Pathogen-Specific T Cells in Peyer's PatchesImmunity, 2006
- Expression of CXCR6 and its ligand CXCL16 in the lung in health and diseaseClinical and Experimental Allergy, 2005
- CCR6 regulates CD4+ T-cell–mediated acute graft-versus-host disease responsesBlood, 2005
- Chemokine‐receptor expression on T cells in lung compartments of challenged asthmatic patientsClinical and Experimental Allergy, 2005
- CCR6 has a non‐redundant role in the development of inflammatory bowel diseaseEuropean Journal of Immunology, 2003
- CC chemokine receptor 6 (CCR6) is a marker for memory T cells that arrest on activated human dermal microvascular endothelium under shear stress.Journal of Investigative Dermatology, 2000
- Two subsets of memory T lymphocytes with distinct homing potentials and effector functionsNature, 1999
- The chemokine receptors CXCR3 and CCR5 mark subsets of T cells associated with certain inflammatory reactions.JCI Insight, 1998