Structure of large fragment of Escherichia coli DNA polymerase I complexed with dTMP
- 1 February 1985
- journal article
- research article
- Published by Springer Science and Business Media LLC in Nature
- Vol. 313 (6005), 762-766
- https://doi.org/10.1038/313762a0
Abstract
The 3.3-.ANG. resolution crystal structure of the large proteolytic fragment of E. coli DNA polymerase I complexed with deoxythymidine monophosphate consists of 2 domains, the smaller of which binds Zn-deoxythymidine monophosphate. The most striking feature of the larger domain is a deep crevice of the appropriate size and shape for binding double-stranded B-DNA. A flexible subdomain may allow the enzyme to surround completely the DNA substrate, allowing processive nucleotide polymerization without enzyme dissociation.This publication has 27 references indexed in Scilit:
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