Advances in combating fungal diseases: vaccines on the threshold
- 11 December 2006
- journal article
- review article
- Published by Springer Science and Business Media LLC in Nature Reviews Microbiology
- Vol. 5 (1), 13-28
- https://doi.org/10.1038/nrmicro1537
Abstract
The dramatic increase in fungal diseases in recent years can be attributed to the increased aggressiveness of medical therapy and other human activities. Immunosuppressed patients are at risk of contracting fungal diseases in healthcare settings and from natural environments. Increased prescribing of antifungals has led to the emergence of resistant fungi, resulting in treatment challenges. These concerns, together with the elucidation of the mechanisms of protective immunity against fungal diseases, have renewed interest in the development of vaccines against the mycoses. Most research has used murine models of human disease and, as we review in this article, the knowledge gained from these studies has advanced to the point where the development of vaccines targeting human fungal pathogens is now a realistic and achievable goal.Keywords
This publication has 203 references indexed in Scilit:
- Multivalent Recombinant Protein Vaccine against CoccidioidomycosisInfection and Immunity, 2006
- Hybridoma Passage In Vitro May Result in Reduced Ability of Antimannan Antibody To Protect against Disseminated CandidiasisInfection and Immunity, 2006
- High Levels of Interleukin-10 Impair Resistance to Pulmonary Coccidioidomycosis in Mice in Part through Control of Nitric Oxide Synthase 2 ExpressionInfection and Immunity, 2006
- CD4+ T cell-independent DNA vaccination against opportunistic infectionsJCI Insight, 2005
- Aspergillus fumigatus Triggers Inflammatory Responses by Stage-Specific β-Glucan DisplayPLoS Pathogens, 2005
- Synthesis of Glycoconjugate Vaccines for Candida albicans Using Novel Linker MethodologyThe Journal of Organic Chemistry, 2005
- Management of Infections in the Neutropenic PatientAnnual Review of Medicine, 2004
- TLR9 signals after translocating from the ER to CpG DNA in the lysosomeNature Immunology, 2004
- Neutropenia alters lung cytokine production in mice and reduces their susceptibility to pulmonary cryptococcosisEuropean Journal of Immunology, 2003
- Antibodies Elicited by a Cryptococcus neoformans-Tetanus Toxoid Conjugate Vaccine Have the Same Specificity as Those Elicited in InfectionThe Journal of Infectious Diseases, 1992