More effective drugs lead to harder selective sweeps in the evolution of drug resistance in HIV-1
Open Access
- 14 February 2016
- journal article
- Published by eLife Sciences Publications, Ltd in eLife
- Vol. 5, e10670
- https://doi.org/10.7554/elife.10670
Abstract
More effective drugs lead to harder selective sweeps in the evolution of drug resistance in HIV-1 | The transition from bad to good treatments for HIV was accompanied by a shift from soft sweeps of many drug resistance mutations spreading simultaneously to harder sweeps of one drug resistant genotype at a time.Keywords
Funding Information
- National Institutes of Health (R01 AI068581)
- National Science Foundation (NSF GRFP, DGE-114747)
- National Institutes of Health (R01 GM100366)
- National Institutes of Health (R01 GM097415)
This publication has 43 references indexed in Scilit:
- Molecular Characterization of Ambiguous Mutations in HIV-1 Polymerase Gene: Implications for Monitoring HIV Infection Status and Drug ResistancePLOS ONE, 2013
- Viral fitness cost prevents HIV-1 from evading dolutegravir drug pressureRetrovirology, 2013
- Selective bird predation on the peppered moth: the last experiment of Michael MajerusBiology Letters, 2012
- The role of G protein gene GNB3 C825TPolymorphism in HIV-1 acquisition, progression and immune activationRetrovirology, 2012
- Ambiguous Nucleotide Calls From Population-based Sequencing of HIV-1 are a Marker for Viral Diversity and the Age of InfectionClinical Infectious Diseases, 2011
- Evidence that Adaptation in Drosophila Is Not Limited by Mutation at Single SitesPLoS Genetics, 2010
- Drug Resistance Mutations for Surveillance of Transmitted HIV-1 Drug-Resistance: 2009 UpdatePLOS ONE, 2009
- Rapid Experimental Evolution of Pesticide Resistance in C. elegans Entails No Costs and Affects the Mating SystemPLOS ONE, 2008
- The Fitness Cost of Mutations Associated with Human Immunodeficiency Virus Type 1 Drug Resistance Is Modulated by Mutational InteractionsJournal of Virology, 2007
- Soft Sweeps III: The Signature of Positive Selection from Recurrent MutationPLoS Genetics, 2006