Antimycobacterial and antioxidant flavones fromLimnophila geoffrayi

Abstract

The chloroform extract of the aerial part ofLimnophila geoffrayi showed antimycobacterial and antioxidant activities. Bioassay-guided fractionation has led to the isolation of the flavones nevadensin (5,7-dihydroxy-6,8,4′-trimethoxyflavone,1) and isothymusin (6,7-dimethoxy-5,8,4′-trihydroxyflavone,2). Both compounds 1 and 2 exhibited inhibition activity againstMycobacterium tuberculosis, with equal MIC value of 200 μg/mL Only compound2 exhibited antioxidant activity against the radical scavenging ability of DPPH, with the IC₅₀ value of 7.7 μg/mL The crude hexane, chloroform and methanol extracts as well as the pure compounds1 and2 did not exhibit mutagenic activity in theBacillus subtilis recassay.