Development of comprehensive disease assessment in systemic vasculitis.
- 25 May 2006
- journal article
- review article
- Vol. 66 (3), 283-92
Abstract
The systemic vasculitides are multisystem disorders with considerable mortality and morbidity and frequent relapses. In the absence of reliable serological markers, accurate clinical tools are required to assess disease activity and damage for treatment decisions, and for the performance of clinical trials. This article reviews and summarises the development and use of disease assessment tools for determining activity and damage in systemic vasculitis and reports ongoing initiatives for further development of disease assessment tools. A literature search was conducted using PubMed and reference lists for vasculitis, assessment, clinical trials, outcome and prognosis. The findings indicate that comprehensive disease assessment in vasculitis requires documentation of disease activity, chronic irreversible damage and impairment of function.Keywords
This publication has 54 references indexed in Scilit:
- Rituximab for Refractory Wegener's GranulomatosisAmerican Journal of Respiratory and Critical Care Medicine, 2006
- Primary systemic vasculitis: clinical features and mortalityQJM: An International Journal of Medicine, 2005
- Outcome of ANCA-associated renal vasculitis: a 5-year retrospective studyAmerican Journal of Kidney Diseases, 2003
- Long-term followup of polyarteritis nodosa, microscopic polyangiitis, and Churg-Strauss syndrome: Analysis of four prospective trials including 278 patientsArthritis & Rheumatism, 2001
- Intravenous immunoglobulin for ANCA-associated systemic vasculitis with persistent disease activityQJM: An International Journal of Medicine, 2000
- The socioeconomic impact of vasculitisCurrent Opinion in Rheumatology, 2000
- Validity of a vasculitis activity index for systemic necrotizing vasculitisArthritis & Rheumatism, 1999
- Limitations of the 1990 American College of Rheumatology Classification Criteria in the Diagnosis of VasculitisAnnals of Internal Medicine, 1998
- Damage occurs early in systemic vasculitis and is an index of outcome.QJM: An International Journal of Medicine, 1997
- Modified disease activity scores that include twenty-eight-joint counts development and validation in a prospective longitudinal study of patients with rheumatoid arthritisArthritis & Rheumatism, 1995