Circulating Demyelinating Factors in Acute Idiopathic Polyneuropathy
- 1 February 1971
- journal article
- research article
- Published by American Medical Association (AMA) in Archives of Neurology
- Vol. 24 (2), 136-144
- https://doi.org/10.1001/archneur.1971.00480320064006
Abstract
Sera from 26 of 31 patients with the Guillain-Barré syndrome (GBS) demyelinated peripheral nervous tissue cultures. The GBS sera produced primary demyelination rather than Wallerian degeneration. Demyelination was complement-dependent. Cytotoxic effects were limited to neural tissue. Fractionation of sera revealed demyelinating activity in both 19S and 7S fractions. Serum demyelinating factors were not specific for GBS and were also found in some patients with other neurologic disordersThis publication has 18 references indexed in Scilit:
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