PDF file - 809K, Table S1 List of genes deregulated in IRE1_DN cells. Table S2 Potential IRE1 cleavage sites on PER1 mRNA. Table S3 Characteristics of human glioma biopsies used in this study. Table S4 Primer Pairs used for PCR and qPCR studies. Table S5 siRNA sequences. Figure S1 PER1 mRNA expression in IRE1 signaling deficient cells. Figure S2 Validation of ski2, xrn1/2 siRNA efficacy. Figure S3 Potential IRE1 cleavage sites on PER1 mRNA. Figure S4 Expression of PER1 mRNA in PER1 silenced cells. Figure S5 XBP1s expression in glioma biopsies by immunohistochemistry. Figure S6: stress independent regulation of PER1 by IRE1α. Figure S7: (A) Two-dimensional modeling of potential Per1 mRNA cleavage sites using the M-Fold program. (B) In vitro RNA cleavage assay. Figure S8: Expression of Per1 mRNA in U87 cells upon lentiviral transduction. Figure S9: determination of protein (A-D) and mRNA (E) expression levels of potential PER1 targets in EV and IRE_DN cells transduced or not with shPER1. Figure S10: impact of CXCL3 re-expression on cell proliferation and neurosphere formation in IRE1_DN cells. Figure S11: (A-F) Immunohistochemical analysis of 3 typical glioblastoma paraffin sections using anti sXBP1 antibodies.