Tumor angiogenesis correlates with progression after radical prostatectomy but not with pathologic stage in gleason sum 5 to 7 adenocarcinoma of the prostate
- 15 February 1997
- Vol. 79 (4), 772-779
- https://doi.org/10.1002/(sici)1097-0142(19970215)79:4<772::aid-cncr14>3.0.co;2-x
Abstract
Prior studies have suggested that tumor angiogenesis (microvessel density [MVD]) may be of prognostic significance in patients with prostate carcinoma. The authors examined the relationship of MVD in intermediate grade prostate carcinomas with stage at radical prostatectomy (RP) and progression after RP. For the former group, 109 RP specimens with Gleason sums of 6 and 7 were studied: 34 organ-confined tumors, 37 with capsular penetration, 21 with seminal vesicle involvement, and 17 with pelvic lymph node metastasis. For the latter group, 87 RP specimens were studied that had a Gleason sum of 5 to 7 for which the patients underwent follow-up of at least 7 years or until progression. Thirty-seven patients (43%) progressed at a mean of 3.5 years (range, 1-8 years). Representative sections of each tumor were stained for CD31 and "hot spot" microvessels were quantitated in a 3.14-mm2 area. In the first arm, there was no relationship between MVD and stage at RP. In the second arm, the mean MVD in tumors that progressed was significantly higher than in nonprogressors (43.0 ± 26.1 vs. 29.0 ± 13.1; P < 0.0001 by Wilcoxon-Gehan statistic). MVD and Gleason sum were independent statistically significant predictors of progression (MVD, P < 0.0001; Gleason sum, P < 0.0001 by Cox proportional hazards model). MVD is an independent significant predictor of progression after RP for tumors with a Gleason sum of 5 to 7. Because these comprise the majority of RP specimens, it is this group for which discrimination of biologic potential is most needed. Angiogenesis may be useful in the prognostic stratification of patients beyond that possible using stage and grade alone. Cancer 1997; 79:772-9. © 1997 American Cancer Society.Keywords
This publication has 26 references indexed in Scilit:
- Tumor Angiogenesis and Metastasis — Correlation in Invasive Breast CarcinomaNew England Journal of Medicine, 1991
- Metastasis and AngiogenesisActa Oncologica, 1990
- Induction of angiogenesis during the transition from hyperplasia to neoplasiaNature, 1989
- Neovascularization in human cutaneous melanoma: A quantitative morphological and Doppler ultrasound studyEuropean Journal of Cancer and Clinical Oncology, 1986
- The significance of atypical vessels and neovascularization in cervical neoplasiaAmerican Journal of Obstetrics and Gynecology, 1981
- Angiogenic Activity as a Marker of Neoplastic and Preneoplastic Lesions of the Human BladderAnnals of Surgery, 1980
- Angiogenesis as a marker of preneoplastic lesions of the human breastCancer, 1978
- TUMOR DORMANCY IN VIVO BY PREVENTION OF NEOVASCULARIZATIONThe Journal of Experimental Medicine, 1972
- Latent carcinoma of the prostateThe Journal of Pathology and Bacteriology, 1954
- HETEROLOGOUS TRANSPLANTATION OF MAMMALIAN TUMORSThe Journal of Experimental Medicine, 1941