Selenium and the prevention of prostate and colorectal cancer
- 6 November 2008
- journal article
- review article
- Published by Wiley in Molecular Nutrition & Food Research
- Vol. 52 (11), 1261-1272
- https://doi.org/10.1002/mnfr.200800103
Abstract
Prostate and colorectal cancers are among the most common cancers and identifying modifiable risk factors are important steps to reduce the burden of these severe diseases. Results from several but mostly small observational studies as well as the secondary analysis of an intervention trial provide support for a chemopreventive effect of selenium on prostate and colorectal cancers. Results suggest effect modification by gender and smoking, but this interpretation is limited by the statistical power of previous studies. Several cancer preventive mechanisms have been described and it is likely that selenium acts through multiple pathways. In particular, the anti‐oxidative and anti‐inflammatory effects mediated through activity of selenoenzymes are discussed, given the relevance of oxidative stress and inflammation in these cancers. Genetic variation in selenoenzymes may modify the potential chemopreventive effect of selenium and need to be further investigated. Additional large observational studies using biomarkers of selenium intake and intervention trials, such as the Selenium and Vitamin E Cancer Prevention Trial, will be important to further evaluate the potential chemopreventive effect of selenium. Furthermore, characterization of functional effects of polymorphisms in selenoenzymes is needed.Keywords
This publication has 150 references indexed in Scilit:
- Common sequence variants on 2p15 and Xp11.22 confer susceptibility to prostate cancerNature Genetics, 2008
- A genome-wide association study shows that common alleles of SMAD7 influence colorectal cancer riskNature Genetics, 2007
- Genome-wide association scan identifies a colorectal cancer susceptibility locus on chromosome 8q24Nature Genetics, 2007
- A genome-wide association scan of tag SNPs identifies a susceptibility variant for colorectal cancer at 8q24.21Nature Genetics, 2007
- Inflammation in prostate carcinogenesisNature Reviews Cancer, 2007
- Assessment of requirements for selenium and adequacy of selenium status: a reviewEuropean Journal of Clinical Nutrition, 2004
- Expression pattern of gastrointestinal selenoproteins— targets for selenium supplementationNutrition and Cancer, 1998
- Plasma selenium levels and the risk of colorectal adenomasNutrition and Cancer, 1997
- Role of oxygen free radicals in cancer developmentEuropean Journal of Cancer, 1996
- Urinary Selenium Status of Healthy Peoplecclm, 1995