Spectrofluorimetric Determination of Three Pharmaceutical Thiocompounds and Allopurinol Using Mercurochrome
- 1 February 1990
- journal article
- research article
- Published by Informa UK Limited in Spectroscopy Letters
- Vol. 23 (2), 161-173
- https://doi.org/10.1080/00387019008054044
Abstract
A new, simple and sensitive fluorimetric method for the determination of three pharmaceutical thiocompounds: cimetidine, thiabendazole and carbimazole, and also allopurinol, has been presented. The method is based on the fluorescence quenching of mercurochrome (MER) in an aqueous alkaline medium. Calibration graphs correlating the fluorescence difference (Fo-F) or the fluoresence ratio (Fo/F) of MER before (Fo) and after (F) quencher addition versus the concentration of the latter are linear. Such linearity permitted the successful application ofKeywords
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