Fetal ethanol exposure increases ethanol intake by making it smell and taste better
- 31 March 2009
- journal article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences of the United States of America
- Vol. 106 (13), 5359-5364
- https://doi.org/10.1073/pnas.0809804106
Abstract
Human epidemiologic studies reveal that fetal ethanol exposure is highly predictive of adolescent ethanol avidity and abuse. Little is known about how fetal exposure produces these effects. It is hypothesized that fetal ethanol exposure results in stimulus-induced chemosensory plasticity. Here, we asked whether gestational ethanol exposure increases postnatal ethanol avidity in rats by altering its taste and odor. Experimental rats were exposed to ethanol in utero via the dam's diet, whereas control rats were either pair-fed an iso-caloric diet or given food ad libitum. We found that fetal ethanol exposure increased the taste-mediated acceptability of both ethanol and quinine hydrochloride (bitter), but not sucrose (sweet). Importantly, a significant proportion of the increased ethanol acceptability could be attributed directly to the attenuated aversion to ethanol's quinine-like taste quality. Fetal ethanol exposure also enhanced ethanol intake and the behavioral response to ethanol odor. Notably, the elevated intake of ethanol was also causally linked to the enhanced odor response. Our results demonstrate that fetal exposure specifically increases ethanol avidity by, in part, making it taste and smell better. More generally, they establish an epigenetic chemosensory mechanism by which maternal patterns of drug use can be transferred to offspring. Given that many licit (e.g., tobacco products) and illicit (e.g., marijuana) drugs have noteworthy chemosensory components, our findings have broad implications for the relationship between maternal patterns of drug use, child development, and postnatal vulnerability.Keywords
This publication has 49 references indexed in Scilit:
- Gestational ethanol exposure alters the behavioral response to ethanol odor and the expression of neurotransmission genes in the olfactory bulb of adolescent ratsBrain Research, 2009
- The consequence of fetal ethanol exposure and adolescent odor re-exposure on the response to ethanol odor in adolescent and adult ratsBehavioral and Brain Functions, 2009
- Reduced Oral Ethanol Avoidance in Mice Lacking Transient Receptor Potential Channel Vanilloid Receptor 1Behavior Genetics, 2008
- Time-specific effects of ethanol exposure on cranial nerve nuclei: Gastrulation and neuronogenesisExperimental Neurology, 2007
- The International Society for Developmental Psychobiology 39th Annual Meeting Symposium: Alcohol and Development: Beyond fetal alcohol syndromeDevelopmental Psychobiology, 2007
- The effect of gestational ethanol exposure on voluntary ethanol intake in early postnatal and adult rats.Behavioral Neuroscience, 2007
- Experience-induced fetal plasticity: The effect of gestational ethanol exposure on the behavioral and neurophysiologic olfactory response to ethanol odor in early postnatal and adult rats.Behavioral Neuroscience, 2007
- Specific enhancement of olfactory receptor sensitivity associated with foetal learning of food odors in the rabbitThe Science of Nature, 1995
- Early olfactory learning induces an enhanced olfactory bulb response in young ratsDevelopmental Brain Research, 1986
- Early experience with sour and bitter solutions increases subsequent ingestionPhysiology & Behavior, 1979