Effects of inspiratory pause on CO2 elimination and arterial Pco2 in acute lung injury
- 1 December 2008
- journal article
- research article
- Published by American Physiological Society in Journal of Applied Physiology
- Vol. 105 (6), 1944-1949
- https://doi.org/10.1152/japplphysiol.90682.2008
Abstract
A high respiratory rate associated with the use of small tidal volumes, recommended for acute lung injury (ALI), shortens time for gas diffusion in the alveoli. This may decrease CO2 elimination. We hypothesized that a postinspiratory pause could enhance CO2 elimination and reduce PaCO2 by reducing dead space in ALI. In 15 mechanically ventilated patients with ALI and hypercapnia, a 20% postinspiratory pause (Tp20) was applied during a period of 30 min between two ventilation periods without postinspiratory pause (Tp0). Other parameters were kept unchanged. The single breath test for CO2 was recorded every 5 min to measure tidal CO2 elimination (VtCO2), airway dead space (VDaw), and slope of the alveolar plateau. PaO2, PaCO2, and physiological and alveolar dead space (VDphys, VDalv) were determined at the end of each 30-min period. The postinspiratory pause, 0.7 ± 0.2 s, induced on average 2O of intrinsic positive end-expiratory pressure (PEEP). During Tp20, VtCO2 increased immediately by 28 ± 10% (14 ± 5 ml per breath compared with 11 ± 4 for Tp0) and then decreased without reaching the initial value within 30 min. The addition of a postinspiratory pause significantly decreased VDaw by 14% and VDphys by 11% with no change in VDalv. During Tp20, the slope of the alveolar plateau initially fell to 65 ± 10% of baseline value and continued to decrease. Tp20 induced a 10 ± 3% decrease in PaCO2 at 30 min (from 55 ± 10 to 49 ± 9 mmHg, P < 0.001) with no significant variation in PaO2. Postinspiratory pause has a significant influence on CO2 elimination when small tidal volumes are used during mechanical ventilation for ALI.Keywords
This publication has 22 references indexed in Scilit:
- CO2elimination at varying inspiratory pause in acute lung injuryClinical Physiology and Functional Imaging, 2007
- Pulmonary Dead-Space Fraction as a Risk Factor for Death in the Acute Respiratory Distress SyndromeThe New England Journal of Medicine, 2002
- Partitioning of dead space ‐ a method and reference values in the awake humanEuropean Respiratory Journal, 2000
- Ventilation with Lower Tidal Volumes as Compared with Traditional Tidal Volumes for Acute Lung Injury and the Acute Respiratory Distress SyndromeThe New England Journal of Medicine, 2000
- The static pressure-volume relationship of the respiratory systemdetermined with a computer-controlled ventilatorClinical Physiology and Functional Imaging, 1997
- Oxygenation remains unaffected by increased inspiration-to-expiration ratio but impairs hemodynamics in surfactant-depleted pigletsIntensive Care Medicine, 1996
- Effects of Pressure-controlled with Different IAnesthesiology, 1994
- Carbon dioxide production during mechanical ventilationCritical Care Medicine, 1987
- Modes of artificial ventilation in severe respiratory distress syndrome. Lung function and morphology in rabbits after wash-out of alveolar surfactantCritical Care Medicine, 1982
- Effect of Mechanical Ventilation with End-inspiratory Pause on Blood-Gas ExchangeAnesthesia & Analgesia, 1976