Protein encoded by v-erbA functions as a thyroid-hormone receptor antagonist
- 1 June 1989
- journal article
- Published by Springer Science and Business Media LLC in Nature
- Vol. 339 (6226), 593-597
- https://doi.org/10.1038/339593a0
Abstract
The thyroid-hormone receptor can, in the absence of its ligand, suppress activity of a responsive promoter. Addition of thyroid hormone, however, results in the stimulation of expression. The oncogenic derivative of the thyroid-hormone receptor, v-erbA, acts as a constitutive repressor and, when coexpressed with the receptor, blocks activation by thyroid hormone. Thus, v-erbA may be the first example of a dominant negative oncogene.Keywords
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