Efficient delivery of siRNA for inhibition of gene expression in postnatal mice
- 29 July 2002
- journal article
- Published by Springer Science and Business Media LLC in Nature Genetics
- Vol. 32 (1), 107-108
- https://doi.org/10.1038/ng944
Abstract
It has recently been shown that RNA interference can be induced in cultured mammalian cells by delivery of short interfering RNAs (siRNAs). Here we describe a method for efficient in vivo delivery of siRNAs to organs of postnatal mice and demonstrate effective and specific inhibition of transgene expression in a variety of organs.This publication has 14 references indexed in Scilit:
- Specific interference with gene expression induced by long, double-stranded RNA in mouse embryonal teratocarcinoma cell linesProceedings of the National Academy of Sciences of the United States of America, 2001
- Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cellsNature, 2001
- RNA Interference and Small Interfering RNAsChemBioChem, 2001
- RNA interference is mediated by 21- and 22-nucleotide RNAsGenes & Development, 2001
- Functional Anatomy of a dsRNA TriggerMolecular Cell, 2000
- dsRNA-mediated gene silencing in cultured Drosophila cells: a tissue culture model for the analysis of RNA interferenceGene, 2000
- RNAi: Double-Stranded RNA Directs the ATP-Dependent Cleavage of mRNA at 21 to 23 Nucleotide IntervalsCell, 2000
- An RNA-directed nuclease mediates post-transcriptional gene silencing in Drosophila cellsNature, 2000
- Specific interference with gene function by double-stranded RNA in early mouse developmentNature, 1999
- Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegansNature, 1998