Primary epithelial tumour in the right atrium of the heart and inferior vena cava in NZR/Gd inbred rats; pathology of 18 cases
- 1 August 1975
- journal article
- research article
- Published by Wiley in The Journal of Pathology
- Vol. 116 (4), 239-251
- https://doi.org/10.1002/path.1711160407
Abstract
In NZR/Gd inbred albino rats, tumours occurred in the right atrium or inferior vena cava of approximately 20 per cent. of untreated animals, of both sexes, over the age of 1 yr. The tumours were centred in the wall of the right atrium in 15 cases, and in the inferior vena cava in another three cases; they appeared to be primary in these sites. The tumours were slowly growing, but eventually malignant. Light- and electron-microscopic study showed the tumours were composed of epithelial alveoli imbedded in a collagenous connective tissue containing spindle cells and thin-walled blood capillaries. The epithelium varied from flat to low columnar, and often secreted mucoid material into the lumina, or sometimes into surrounding tissue. This tumour, for which the name atrio-caval epithelial mesothelioma is suggested, very closely resembles a rare epithelial tumour of the right atrium previously described in humans under a variety of names. An underlying embryological anomaly had been postulated in these tumours in humans, and the occurrence of pathologically similar lesions in high incidence in hearts of NZR/Gd inbred rats should help test the hypothesis of genetic and developmental causes in the genesis of this rare cardiac neoplasm.Keywords
This publication has 11 references indexed in Scilit:
- An electron microscope study of the production of ascities in acute dimethylnitrosamine (DMN)-induced liver injuryThe Journal of Pathology, 1973
- The GH and AS hypertensive rat strainsLaboratory Animals, 1973
- Presence of modified fibroblasts in granulation tissue and their possible role in wound contractionCellular and Molecular Life Sciences, 1971
- Erzeugung neurogener Malignome durch einmalige Gabe von Äthyl-nitrosoharnstoff (ÄNH) an neugeborene und junge BD IX-RattenZeitschrift für Krebsforschung und Klinische Onkologie, 1970
- A low-viscosity epoxy resin embedding medium for electron microscopyJournal of Ultrastructure Research, 1969
- INTRACARDIAC ENDODERMAL HETEROTOPIAHeart, 1962
- Le Cœlothéliome fawarien béninJMIR AI, 1942
- Lymphangio‐Endothelioma of the heart causing complete heaet blockThe Journal of Pathology and Bacteriology, 1934
- Über die Bedeutung der Venae minimae Thebesii für die Blutversorgung des HerzmuskelsVirchows Archiv, 1928
- Ein Beitrag zur Kenntnis der angeborenen Rhabdomyome des HerzensVirchows Archiv, 1921