Genome-wide association analysis identifies 30 new susceptibility loci for schizophrenia
- 31 October 2017
- journal article
- research article
- Published by Springer Science and Business Media LLC in Nature Genetics
- Vol. 49 (11), 1576-+
- https://doi.org/10.1038/ng.3973
Abstract
We conducted a genome-wide association study (GWAS) with replication in 36,180 Chinese individuals and performed further transancestry meta-analyses with data from the Psychiatry Genomics Consortium (PGC2). Approximately 95% of the genome-wide significant (GWS) index alleles (or their proxies) from the PGC2 study were overrepresented in Chinese schizophrenia cases, including similar to 50% that achieved nominal significance and similar to 75% that continued to be GWS in the transancestry analysis. The Chinese-only analysis identified seven GWS loci; three of these also were GWS in the transancestry analyses, which identified 109 GWS loci, thus yielding a total of 113 GWS loci (30 novel) in at least one of these analyses. We observed improvements in the fine-mapping resolution at many susceptibility loci. Our results provide several lines of evidence supporting candidate genes at many loci and highlight some pathways for further research. Together, our findings provide novel insight into the genetic architecture and biological etiology of schizophrenia.This publication has 72 references indexed in Scilit:
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