Macrophage-colony-stimulating factor selectively enhances macrophage scavenger receptor expression and function.
Open Access
- 1 August 1994
- journal article
- Published by Rockefeller University Press in The Journal of Experimental Medicine
- Vol. 180 (2), 705-709
- https://doi.org/10.1084/jem.180.2.705
Abstract
Regulation of macrophage scavenger receptor (MSR) activity may be an important determinant of the extent of atherogenesis. The effect of macrophage-colony-stimulating factor (M-CSF) on this pathway was studied using a recently developed monoclonal antibody to murine MSR. M-CSF markedly and selectively increased MSR synthesis in murine macrophages: posttranslationally, the receptor appeared more stable and shifted to a predominantly surface distribution. Functionally, M-CSF enhanced modified lipoprotein uptake and increased divalent cation-independent adhesion in vitro. These results suggest a plausible mechanism whereby M-CSF production in the atheromatous plaque microenvironment could promote the recruitment and retention of mononuclear phagocytes and subsequent foam cell formation.Keywords
This publication has 22 references indexed in Scilit:
- Divalent cation-independent macrophage adhesion inhibited by monoclonal antibody to murine scavenger receptorNature, 1993
- Structures and high and low affinity ligand binding properties of murine type I and type II macrophage scavenger receptorsJournal of Lipid Research, 1993
- Molecular flypaper, host defense, and atherosclerosis. Structure, binding properties, and functions of macrophage scavenger receptors.Journal of Biological Chemistry, 1993
- Structure, organization, and chromosomal mapping of the human macrophage scavenger receptor gene.Journal of Biological Chemistry, 1993
- Transport of the lysosomal membrane glycoprotein lgp120 (lgp-A) to lysosomes does not require appearance on the plasma membraneThe Journal of cell biology, 1992
- Interferon-gamma inhibits scavenger receptor expression and foam cell formation in human monocyte-derived macrophages.JCI Insight, 1992
- Receptors for modified low-density lipoproteins on human endothelial cells: different recognition for acetylated low-density lipoprotein and oxidized low-density lipoproteinBiochimica et Biophysica Acta (BBA) - Molecular Cell Research, 1991
- Induction of endothelial cell expression of granulocyte and macrophage colony-stimulating factors by modified low-density lipoproteinsNature, 1990
- Inducible production of human macrophage growth factor, CSF-1.1986
- Binding site on macrophages that mediates uptake and degradation of acetylated low density lipoprotein, producing massive cholesterol depositionProceedings of the National Academy of Sciences of the United States of America, 1979