Hepatitis C and hepatitis B-related mortality in Spain
- 1 August 2009
- journal article
- review article
- Published by Ovid Technologies (Wolters Kluwer Health) in European Journal of Gastroenterology & Hepatology
- Vol. 21 (8), 895-901
- https://doi.org/10.1097/meg.0b013e328313139d
Abstract
Although hepatitis C and hepatitis B virus (HCV/HBV) infections are an important health problem worldwide, their burden of disease (BoD) taking into account their chronic consequences, cirrhosis, and hepatocellular carcinoma (HCC), is still unknown. Our aim was to assess the total number of deaths attributable to these viruses in Spain and the years of life lost, first component of the disability adjusted life years, a comparative index of BoD.We selected the International Classification of Diseases-Tenth Revision specific codes related to HCV/HBV. For unspecified cirrhosis and HCC, the attributable fraction of mortality was assessed in two steps: literature review and expert panel. Deaths in Spain in 2000 were obtained from the National Statistics Institute. Years of life lost were calculated using the estimated mortality and life expectancies (Princeton Model Life Table).HCV could have caused around 70% of HCC deaths and 50% of cirrhosis mortality in Spain in 2000 (60% HCC, 40% cirrhosis with HCV lower estimate). For HBV these proportions are 10 and 13%, respectively. We estimated 4342 HCV-related deaths and 877 HBV-related deaths in Spain in 2000, globally 1.5% of total deaths in Spain that year. Mortality by cirrhosis and HCC represented most of these viral-related deaths. Attributable mortality in AIDS patients was also estimated.HCV leads the list of infectious disease-related mortality in Spain in 2000, doubling the AIDS mortality even if lower HCV attributable fractions are considered. Exclusion of cirrhosis and HCC-related mortality severely underestimates the BoD attributable to HCV/HBV. Improving early diagnosis and access to treatment could have an important impact on mortality because of hepatitis virus in the next decades.Keywords
This publication has 42 references indexed in Scilit:
- Epidemiology of hepatocellular carcinoma in areas of low hepatitis B and hepatitis C endemicityOncogene, 2006
- The contributions of hepatitis B virus and hepatitis C virus infections to cirrhosis and primary liver cancer worldwideJournal of Hepatology, 2006
- Hepatitis Viruses, Alcohol, and Tobacco in the Etiology of Hepatocellular Carcinoma in ItalyCancer Epidemiology, Biomarkers & Prevention, 2006
- Hepatocellular carcinoma in cirrhosis: Incidence and risk factorsGastroenterology, 2004
- Sensibilidad de género en la formulación de planes de salud en España: lo que pudo ser y no fueGaceta Sanitaria, 2004
- Global Burden of Disease (GBD) for Hepatitis CThe Journal of Clinical Pharmacology, 2004
- Report of the First International Liver Transplantation Society Expert Panel Consensus Conference on liver transplantation and hepatitis CLiver Transplantation, 2003
- Epidemiology of Hepatocellular CarcinomaCanadian Journal of Gastroenterology, 2000
- Impact of HBV, HCV and GBV-C/HGV on hepatocellular carcinomas in Europe: results of a European concerted actionJournal of Hepatology, 1998
- PREVALENCE OF ANTIBODIES TO HEPATITIS C VIRUS IN SPANISH PATIENTS WITH HEPATOCELLULAR CARCINOMA AND HEPATIC CIRRHOSISThe Lancet, 1989