Lymphocytic Esophagitis in Children
Open Access
- 1 August 2014
- journal article
- research article
- Published by Oxford University Press (OUP) in Inflammatory Bowel Diseases
- Vol. 20 (8), 1324-1328
- https://doi.org/10.1097/mib.0000000000000100
Abstract
Lymphocytic esophagitis (LE) is a term recently suggested for the finding of >20 intraepithelial lymphocytes/high-power field in an esophageal biopsy with no more than a rare granulocyte. Two prior studies of LE suggested an association of LE with Crohn's disease (CD) in young patients, but there has been no systematic review of a large pediatric cohort to determine the prevalence and clinical associations of LE in children. All esophageal biopsies performed at a tertiary care pediatric medical center in 2005 were identified (580 biopsies from 545 unique patients). A blinded histologic review was performed to identify LE cases (>50 intraepithelial lymphocytes/high-power field; P < 0.05). The remaining LE patients had various other clinical diagnoses with no significant clinical correlates. LE was identified in 6 of 49 patients with CD (12.2%) and 25 of 496 patients without CD (5.0%) (P < 0.05). Patients with both LE and CD had a more prominent lymphocytic infiltrate than LE patients without CD. LE seems to be more prevalent in children than in adults and has a significant association with CD in this age group.Keywords
This publication has 14 references indexed in Scilit:
- Lymphocytic EsophagitisJournal of Clinical Gastroenterology, 2012
- Lymphocytic esophagitis: A possible manifestation of pediatric upper gastrointestinal Crohnʼs diseaseInflammatory Bowel Diseases, 2011
- Lymphocytic Disorders of the Gastrointestinal TractAdvances in Anatomic Pathology, 2009
- Lymphocytic EsophagitisAmerican Journal of Clinical Pathology, 2008
- Lymphocytic EsophagitisAmerican Journal of Clinical Pathology, 2006
- Reassessment of the Diagnostic Value of Histology in Patients with GERD, Using Multiple Biopsy Sites and an Appropriate Control GroupThe American Journal of Gastroenterology, 2005
- Crohn’s Disease of the Esophagus: Clinical Features and OutcomesInflammatory Bowel Diseases, 2001
- Assessment and diagnostic utility of the cytotoxic T-lymphocyte phenotype using the specific markers granzyme-B and TIA-1 in esophageal mucosal biopsiesHuman Pathology, 1999
- The Significance of Intraepitheliai Eosinophils in the Histologic Diagnosis of Gastroesophageal RefluxAmerican Journal of Clinical Pathology, 1987
- Intraepithelial eosinophils in endoscopic biopsies of adults with reflux esophagitisThe American Journal of Surgical Pathology, 1984