Erythrocyte Glutathione, Glutathione Peroxidase, Superoxide Dismutase and Serum Lipid Peroxidation in Epileptic Children With Valproate and Carbamazepine Monotherapy
- 1 March 2000
- journal article
- clinical trial
- Published by Walter de Gruyter GmbH in Journal of Basic and Clinical Physiology and Pharmacology
- Vol. 11 (1), 73-81
- https://doi.org/10.1515/jbcpp.2000.11.1.73
Abstract
This prospective study was carried out to determine changes in the antioxidant system in epileptic children receiving long term antiepileptic drugs (AEDs). Levels of erythrocyte glutathione (GSH), glutathione peroxidase (GSH-Px), superoxide dismutase (SOD) and serum lipid peroxidation were determined in 25 healthy children and 30 epileptic children who had not yet received AEDs. Sixteen patients were treated with valproic acid (VPA) and 14 with carbamazepine (CBZ); 13 months later these parameters were retested. The results showed that SOD and lipid peroxidation levels were increased but the GSH-Px levels were decreased in epileptic children on VPA therapy compared with the control group and the results before treatment. No significant differences of these parameters were found in epileptic children on CBZ therapy compared with the control group and the results before treatment, except that lipid peroxidation level was slightly higher in epileptic patients before treatment. We conclude that antioxidant systems in epileptic children on CBZ therapy are better regulated in comparison with epileptic children on VPA therapy.Keywords
This publication has 21 references indexed in Scilit:
- Altered Antioxidant Enzyme Activities in Children with a Serious Adverse Experience Related to Valproic Acid TherapyNeuropediatrics, 1998
- Free radicals, anticonvulsants, and the neuronal ceroid‐lipofuscinosesAmerican Journal of Medical Genetics, 1995
- Inhibition of mitochondrial respiration and oxygen-dependent hepatotoxicity by six structurally dissimilar peroxisomal proliferating agentsToxicology, 1992
- Glutathione peroxidase deficiency and childhood seizuresThe Lancet, 1991
- Oxygen Free Radicals and Brain DysfunctionInternational Journal of Neuroscience, 1991
- Post‐Traumatic Epilepsy: Cellular Mechanisms and Implications for TreatmentEpilepsia, 1990
- Central nervous system trauma and stroke: II. Physiological and pharmacological evidence for involvement of oxygen radicals and lipid peroxidationFree Radical Biology & Medicine, 1989
- Teratogenicity of Antiepileptic Drug Combinations with Special Emphasis on Epoxidation (of Carbamazepine)Epilepsia, 1984
- Metabolic activation and drug toxicityJournal of Medicinal Chemistry, 1982
- International Committee for Standardization in Haematology: Recommended Methods for Red‐Cell Enzyme Analysis*British Journal of Haematology, 1977