miR‐342‐3p suppresses proliferation, migration and invasion by targeting FOXM1 in human cervical cancer
Open Access
- 24 July 2014
- journal article
- Published by Wiley in FEBS Letters
- Vol. 588 (17), 3298-3307
- https://doi.org/10.1016/j.febslet.2014.07.020
Abstract
FOXM1 is a well‐established oncogenic factor that has been reported to be involved in multiple biological processes including cell proliferation, growth, angiogenesis, migration and invasion. It can also be regulated by miRNAs. In this study, we reported that FOXM1 is directly targeted by miR‐342‐3p, which is down‐regulated along with its host gene, EVL, in human cervical cancer tissues compared to the adjacent normal tissues. Functional studies suggested that the overexpression of miR‐342‐3p inhibits cell proliferation, migration and invasion in cervical cell lines. FOXM1 is upregulated and negatively correlates with miR‐342‐3p in cervical cancer tissues, and the overexpression of FOXM1 rescues the phenotype changes induced by the overexpression of miR‐342‐3p.Keywords
Funding Information
- Technology Bureau of Qingdao
This publication has 23 references indexed in Scilit:
- miR‐134 inhibits epithelial to mesenchymal transition by targeting FOXM1 in non‐small cell lung cancer cellsFEBS Letters, 2012
- The tumor suppressive role of miRNA-370 by targeting FoxM1 in acute myeloid leukemiaMolecular Cancer, 2012
- Genome-Wide Expression Analysis of Middle Eastern Colorectal Cancer Reveals FOXM1 as a Novel Target for Cancer TherapyThe American Journal of Pathology, 2011
- Young age, increased tumor proliferation and FOXM1 expression predict early metastatic relapse only for endocrine-dependent breast cancersBreast Cancer Research and Treatment, 2011
- Forkhead box M1 transcription factor: A novel target for cancer therapyCancer Treatment Reviews, 2010
- MicroRNAs in CancerAnnual Review of Medicine, 2009
- An integrative genomic approach reveals coordinated expression of intronic miR-335, miR-342, and miR-561 with deregulated host genes in multiple myelomaBMC Medical Genomics, 2008
- Epigenetic silencing of the intronic microRNA hsa-miR-342 and its host gene EVL in colorectal cancerOncogene, 2008
- FoxM1: At the crossroads of ageing and cancerBiochimica et Biophysica Acta (BBA) - Reviews on Cancer, 2006
- Mathematical modeling of noise and discovery of genetic expression classes in gliomasOncogene, 2002