Duodenogastric reflux in rat gastric carcinoma
- 1 October 1986
- journal article
- research article
- Published by Oxford University Press (OUP) in British Journal of Surgery
- Vol. 73 (10), 801-803
- https://doi.org/10.1002/bjs.1800731014
Abstract
This study investigated the role of long-term reflux of bile and/or pancreaticoduodenal secretions in the genesis of gastric carcinoma in the rat. Adenocarcinoma, dysplasia and adenocystic proliferation were found only in those animals with reflux of pancreaticoduodenal secretions alone or in combination with bile. No such changes were found in control animals with no reflux or animals with bile reflux alone. The differences in incidence of adenocarcinoma were significant. The presence of adenocarcinoma was not related to the pH of the intragastric contents or to the bacterial flora. This suggests that duodenogastric reflux is implicated in gastric carcinogenesis in the rat and that pancreaticoduodenal secretions rather than bile are responsible.Keywords
This publication has 5 references indexed in Scilit:
- Cancer following gastric surgeryBritish Journal of Surgery, 1985
- Microflora and deconjugation of bile acids in alkaline reflux after partial gastrectomyThe American Journal of Surgery, 1980
- Gastric carcinoma promoted by alkaline reflux gastritis — With special reference to bile and other surfactants as promoters of postoperative gastric cancerMedical Hypotheses, 1979
- Bacteria and the N-Nitrosation of Secondary AminesBritish Journal of Cancer, 1971
- Quantitative determination of the major 3-hydroxy bile acids in biological material after thin-layer chromatographic separationClinica Chimica Acta; International Journal of Clinical Chemistry, 1970