Risk factors for post-stem cell transplant sinusitis
Open Access
- 1 February 2002
- journal article
- research article
- Published by Springer Science and Business Media LLC in Bone Marrow Transplantation
- Vol. 29 (3), 257-261
- https://doi.org/10.1038/sj.bmt.1703353
Abstract
An understanding of the factors that place the post-transplant patient at increased risk for sinusitis would help identify patients likely to develop disease and possibly allow for interventions that would decrease the incidence or severity of sinus disease. This retrospective study investigates the ability of screening paranasal sinus computed tomographic scans (CTs), clinical history, and potential risk factors for sinusitis, including history of tobacco use, history of allergies or asthma, IgG level, history of sinusitis, remission status and acute graft-versus-host disease (GVHD) to predict post-transplant sinusitis. Medical records and sinus CTs of 100 allogeneic bone marrow recipients were reviewed. There was no increased risk of developing sinusitis post SCT for patients with significant disease on screening CT, symptoms at time of transplant, a history of tobacco use, asthma or allergies, low IgG level, history of sinusitis or for patients at high risk of relapse. Patients with GVHD were 4.3 times more likely than patients without GVHD to develop sinusitis post transplant (95% CI: 1.7–11.0, P = 0.002). Acute GVHD places patients at greater risk of developing sinus infections. Bone Marrow Transplantation (2002) 29, 257–261. doi:10.1038/sj.bmt.1703353Keywords
This publication has 7 references indexed in Scilit:
- Screening sinus CT scans in pediatric bone marrow transplant patientsInternational Journal of Pediatric Otorhinolaryngology, 2000
- Sinus disease in the bone marrow transplant population: Incidence, risk factors,and complicationsOtolaryngology -- Head and Neck Surgery, 1995
- Quantification for Staging SinusitisAnnals of Otology, Rhinology & Laryngology, 1995
- Chronic SinusitisJAMA, 1994
- Risk Factors in the Development of Acute Sinusitis in Immunocompromised PatientsAmerican Journal of Rhinology, 1991
- Recurrent Sinopulmonary Infection and Impaired Antibody Response to Bacterial Capsular Polysaccharide Antigen in Children with Selective IgG-Subclass DeficiencyThe New England Journal of Medicine, 1985
- Sinus disease in children with respiratory allergyJournal of Allergy and Clinical Immunology, 1978