Identifying Risk Factors for Severe Respiratory Syncytial Virus Among Infants Born After 33 Through 35 Completed Weeks of Gestation
- 1 November 2004
- journal article
- Published by Ovid Technologies (Wolters Kluwer Health) in The Pediatric Infectious Disease Journal
- Vol. 23 (11), S193-S201
- https://doi.org/10.1097/01.inf.0000144664.31888.53
Abstract
Prematurity is a proven risk factor for severe respiratory syncytial virus (RSV) infection. Prematurity leads to an increased need for, and duration of, hospital admission, intensive care, mechanical ventilation and supplemental oxygen, as well as increased mortality. The Pediatric Investigators Collaborative Network on Infections in Canada (PICNIC) study was a prospective, multicenter, cohort study conducted in 16 regions across Canada during 2 successive RSV seasons: November 2000-June 2001, and November 2001-June 2002. The study regions were defined to capture all births and all hospital admissions. The FLIP [identify those risk Factors that most Likely may lead to development of RSV-related respiratory Infection and subsequent hospital admission among Premature infants born 33-35 weeks gestational age (GA)] study was a prospective, case-control study comparison of premature infants hospitalized for RSV infection and infants who had not been hospitalized to identify the risk factors that most likely would lead to development of RSV infection and subsequent hospital admission in this population. The overall hospitalization rate for RSV in the PICNIC study was 3.6% for infants of 33-35 weeks GA. In the FLIP study, the severity of RSV infection in the 33- to 35-week GA infants was similar to that in the younger infants of <33-week GA studied previously by the Infeccion Respiratoria Infantil por Virus Respiratorio Sincitial Study Group. Similar risk factors were noted in both studies. RSV is a major cause of hospitalization in preterm infants. There is great variability among hospital admission rates globally, despite the commonality of severe RSV in many countries. Furthermore there are numerous independent risk factors for severe RSV, including socioeconomic and environmental factors, that merit further investigation. There is likely an additive effect when multiple risk factors are present. More research is needed on the various risk factors and their significance.Keywords
This publication has 30 references indexed in Scilit:
- Revised Indications for the Use of Palivizumab and Respiratory Syncytial Virus Immune Globulin Intravenous for the Prevention of Respiratory Syncytial Virus InfectionsPublished by American Academy of Pediatrics (AAP) ,2003
- Impact of severe disease caused by respiratory syncytial virus in children living in developed countriesThe Pediatric Infectious Disease Journal, 2003
- Populations at risk for developing respiratory syncytial virus and risk factors for respiratory syncytial virus severity: infants with predisposing conditionsThe Pediatric Infectious Disease Journal, 2003
- Severe Respiratory Syncytial Virus Disease in Alaska Native ChildrenThe Journal of Infectious Diseases, 1999
- Pediatric Investigators Collaborative Network on Infections in Canada (PICNIC) prospective study of risk factors and outcomes in patients hospitalized with respiratory syncytial viral lower respiratory tract infectionThe Journal of Pediatrics, 1995
- Risk factors for mechanical ventilation in respiratory syncytial virus infectionEuropean Journal of Pediatrics, 1993
- Intensive care course and outcome of patients infected with respiratory syncytial virusPediatric Pulmonology, 1992
- Does prematurity alter the course of respiratory syncytial virus infection?Critical Care Medicine, 1990
- Duration of hospitalization in previously well infants with respiratory syncytial virus infectionThe Pediatric Infectious Disease Journal, 1989
- Pulmonary follow-up of moderately low birth weight infants with and without respiratory distress syndromeThe Journal of Pediatrics, 1987