Periodontal diseases
Top Cited Papers
- 22 June 2017
- journal article
- review article
- Published by Springer Science and Business Media LLC in Nature Reviews Disease Primers
- Vol. 3 (1), nrdp201738
- https://doi.org/10.1038/nrdp.2017.38
Abstract
Periodontal diseases comprise a wide range of inflammatory conditions that affect the supporting structures of the teeth (the gingiva, bone and periodontal ligament), which could lead to tooth loss and contribute to systemic inflammation. Chronic periodontitis predominantly affects adults, but aggressive periodontitis may occasionally occur in children. Periodontal disease initiation and propagation is through a dysbiosis of the commensal oral microbiota (dental plaque), which then interacts with the immune defences of the host, leading to inflammation and disease. This pathophysiological situation persists through bouts of activity and quiescence, until the affected tooth is extracted or the microbial biofilm is therapeutically removed and the inflammation subsides. The severity of the periodontal disease depends on environmental and host risk factors, both modifiable (for example, smoking) and non-modifiable (for example, genetic susceptibility). Prevention is achieved with daily self-performed oral hygiene and professional removal of the microbial biofilm on a quarterly or bi-annual basis. New treatment modalities that are actively explored include antimicrobial therapy, host modulation therapy, laser therapy and tissue engineering for tissue repair and regeneration.Keywords
This publication has 100 references indexed in Scilit:
- Exploring the genetic basis of chronic periodontitis: a genome-wide association studyHuman Molecular Genetics, 2013
- A systematic review on the effects of local antimicrobials as adjuncts to subgingival debridement, compared with subgingival debridement alone, in the treatment of chronic periodontitisJournal of Clinical Periodontology, 2013
- The leukocyte integrin antagonist Del-1 inhibits IL-17-mediated inflammatory bone lossNature Immunology, 2012
- Diabetes mellitus and periodontitis: a tale of two common interrelated diseasesNature Reviews Endocrinology, 2011
- Epidemiologic patterns of chronic and aggressive periodontitisPeriodontology 2000, 2010
- Resolvin D2 is a potent regulator of leukocytes and controls microbial sepsisNature, 2009
- DNA methylation and gene silencing in cancerNature Clinical Practice Oncology, 2005
- Surgical periodontal therapyPeriodontology 2000, 2001
- Bleeding on probing. A parameter for monitoring periodontal conditions in clinical practiceJournal of Clinical Periodontology, 1994
- Scaling and root planing with and without periodontal flap surgeryJournal of Clinical Periodontology, 1986