Norfloxacin Blood-Brain Barrier Transport in Rats Is Not Affected by Probenecid Coadministration
Open Access
- 1 January 2006
- journal article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 50 (1), 371-373
- https://doi.org/10.1128/aac.50.1.371-373.2006
Abstract
The effect of probenecid (PRO) on norfloxacin (NOR) blood-brain barrier transport was investigated with rats by microdialysis. Maximum brain drug concentrations were rapidly attained, and the brain penetration factor was close to 5% in the absence and presence of PRO. In conclusion, PRO has no effect on NOR blood-brain barrier transport.Keywords
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