GW112, A Novel Antiapoptotic Protein That Promotes Tumor Growth
- 1 April 2004
- journal article
- Published by American Association for Cancer Research (AACR) in Cancer Research
- Vol. 64 (7), 2474-2481
- https://doi.org/10.1158/0008-5472.can-03-3443
Abstract
GW112 is a novel gene that has little homology to other known genes. It is overexpressed in a number of human tumor types, especially in those of the digestive system. We show here that GW112 is associated with GRIM-19, a protein known to be involved in regulating cellular apoptosis. Functionally, GW112 could significantly attenuate the ability of GRIM19 to mediate retinoic acid-IFN-β-mediated cellular apoptosis and apoptosis-related gene expression. In addition, GW112 demonstrated strong antiapoptotic effects in tumor cells treated with other stress exposures such as hydrogen peroxide. Finally, forced overexpression of GW112 in murine prostate tumor cells led to more rapid tumor formation in a syngeneic host. Taken together, our data suggest that GW112 is an important regulator of cell death that plays important roles in tumor cell survival and tumor growth.Keywords
This publication has 46 references indexed in Scilit:
- Coordinated regulation of life and death by RBNature Reviews Cancer, 2003
- Validating survivin as a cancer therapeutic targetNature Reviews Cancer, 2003
- Points of control in inflammationNature, 2002
- Bak and Bax Function To Limit Adenovirus Replication through Apoptosis InductionJournal of Virology, 2002
- Apoptosis in Autoimmune Diseases.Internal Medicine, 2001
- Activation of the Cytoplasmic c-Abl Tyrosine Kinase by Reactive Oxygen SpeciesPublished by Elsevier BV ,2000
- The Hallmarks of CancerCell, 2000
- c-Abl tyrosine kinase can mediate tumor cell apoptosis independently of the Rb and p53 tumor suppressorsOncogene, 1998
- Ectopic expression of CHOP (GADD153) induces apoptosis in M1 myeloblastic leukemia cellsFEBS Letters, 1996
- Induction of Apoptotic Program in Cell-Free Extracts: Requirement for dATP and Cytochrome cCell, 1996