Highly substituted pyridines via tethered imine–enamine (TIE) methodology
- 27 January 2004
- journal article
- Published by Royal Society of Chemistry (RSC) in Chemical Communications
- No. 5,p. 508-509
- https://doi.org/10.1039/b316107b
Abstract
A tethered imine–enamine methodology has been developed for the direct conversion of 1,2,4-triazines into highly substituted pyridines via the inverse electron demand Diels–Alder reaction which avoids the need for a discrete aromatisation step. This TIE methodology has also been applied in one pot reaction cascades involving 1,2,4-triazines and utilising MnO2-mediated tandem oxidation processes (TOPs).Keywords
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