The polydeoxyadenylate tract of Alu repetitive elements is polymorphic in the human genome.
- 1 April 1990
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences of the United States of America
- Vol. 87 (8), 2951-2954
- https://doi.org/10.1073/pnas.87.8.2951
Abstract
To identify DNA polymorphisms that are abundant in the human genome and are detectable by polymerase chain reaction amplification of genomic DNA, we tested the hypothesis that the polydeoxyadenylate tract of the Alu family of repetitive elements is polymorphic among human chromosomes. We analyzed the 3' ends of three specific Alu sequences and found that two (in the adenosine deaminase gene and the beta-globin pseudogene) were polymorphic. This novel class of polymorphisms, termed AluVpA [Alu variable poly(A)] may represent one of the most useful and informative group of DNA markers in the human genome.Keywords
This publication has 33 references indexed in Scilit:
- A genetic linkage map of 17 markers on human chromosome 21Genomics, 1989
- Characterization of a nondeleterious L1 insertion in an intron of the human factor VIII gene and further evidence of open reading frames in functional L1 elementsGenomics, 1989
- Primer-Directed Enzymatic Amplification of DNA with a Thermostable DNA PolymeraseScience, 1988
- Complete sequence and structure of the gene for human adenosine deaminaseBiochemistry, 1986
- Enzymatic Amplification of β-Globin Genomic Sequences and Restriction Site Analysis for Diagnosis of Sickle Cell AnemiaScience, 1985
- The Genetic Linkage Map of the Human X ChromosomeScience, 1985
- Sister chromatid exchange and the evolution of rDNA spacer lengthJournal of Theoretical Biology, 1985
- Critical test of a sister chromatid exchange model for the immunoglobulin heavy-chain class switchNature, 1985
- Base sequence studies of 300 nucleotide renatured repeated human DNA clonesJournal of Molecular Biology, 1981
- Detection of specific sequences among DNA fragments separated by gel electrophoresisJournal of Molecular Biology, 1975