Level and course of FEV1 in relation to polymorphisms in NFE2L2 and KEAP1 in the general population
Open Access
- 11 August 2009
- journal article
- research article
- Published by Springer Science and Business Media LLC in Respiratory Research
- Vol. 10 (1), 73
- https://doi.org/10.1186/1465-9921-10-73
Abstract
The metabolism of xenobiotics plays an essential role in smoking related lung function loss and development of Chronic Obstructive Pulmonary Disease. Nuclear Factor Erythroid 2-Like 2 (NFE2L2 or NRF2) and its cytosolic repressor Kelch-like ECH-associated protein-1 (KEAP1) regulate transcription of enzymes involved in cellular detoxification processes and Nfe2l2-deficient mice develop tobacco-induced emphysema. We assessed the impact of Single Nucleotide Polymorphisms (SNPs) in both genes on the level and longitudinal course of Forced Expiratory Volume in 1 second (FEV1) in the general population.Keywords
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