Association Between Noninfectious Uveitis and Psychological Stress

Abstract

Uveitis is a significant cause of ocular morbidity that accounts for 10% to 15% of blindness in the United States.¹ Most uveitis cases worldwide are presumed to be immune-mediated and noninfectious.² In many instances, uveitis is associated with autoimmune disease.^2,3 Animal models and human peripheral blood specimens suggest that uveitis may involve dysregulation of regulatory T lymphocytes in the eye.^4-9 The negative consequences of uveitis on vision are well known, but the effect on mental health has not been as well elucidated.^10-12