Podoplanin: emerging functions in development, the immune system, and cancer
Top Cited Papers
Open Access
- 1 January 2012
- journal article
- Published by Frontiers Media SA in Frontiers in Immunology
- Vol. 3, 283
- https://doi.org/10.3389/fimmu.2012.00283
Abstract
Podoplanin (PDPN) is a well-conserved, mucin-type transmembrane protein expressed in multiple tissues during ontogeny and in adult animals, including the brain, heart, kidney, lungs, osteoblasts, and lymphoid organs. Studies of PDPN-deficient mice have demonstrated that this molecule plays a critical role in development of the heart, lungs, and lymphatic system. PDPN is widely used as a marker for lymphatic endothelial cells and fibroblastic reticular cells of lymphoid organs and for lymphatics in the skin and tumor microenvironment. Much of the mechanistic insight into PDPN biology has been gleaned from studies of tumor cells; tumor cells often upregulate PDPN as they undergo epithelial-mesenchymal transition and this upregulation is correlated with increased motility and metastasis. The physiological role of PDPN that has been most studied is its ability to aggregate and activate CLEC-2-expressing platelets, as PDPN is the only known endogenous ligand for CLEC-2. However, more recent studies have revealed that PDPN also plays crucial roles in the biology of immune cells, including T cells and dendritic cells. This review will provide a comprehensive overview of the diverse roles of PDPN in development, immunology, and cancer.Keywords
This publication has 93 references indexed in Scilit:
- Alveolar Type I Cells: Molecular Phenotype and DevelopmentAnnual Review of Physiology, 2003
- Regulation of Blood and Lymphatic Vascular Separation by Signaling Proteins SLP-76 and SykScience, 2003
- Prox1 is a master control gene in the program specifying lymphatic endothelial cell fateDevelopmental Dynamics, 2002
- Epithelial–mesenchymal transitions in tumour progressionNature Reviews Cancer, 2002
- Splenic T Zone Development Is B Cell DependentThe Journal of Experimental Medicine, 2001
- A novel cluster of lectin-like receptor genes expressed in monocytic, dendritic and endothelial cells maps close to the NK receptor genes in the human NK gene complexEuropean Journal of Immunology, 2001
- Ectopic Lymphoid Organogenesis: A Fast Track for AutoimmunityThe American Journal of Pathology, 2001
- Coexpression of the chemokines ELC and SLC by T zone stromal cells and deletion of the ELC gene in theplt/pltmouseProceedings of the National Academy of Sciences of the United States of America, 2000
- Identification of PA2.26 antigen as a novel cell-surface mucin-type glycoprotein that induces plasma membrane extensions and increased motility in keratinocytesJournal of Cell Science, 1999
- Cloning and characterization of gp36, a human mucin-type glycoprotein preferentially expressed in vascular endothelium.1999