Activation of the c- myb Locus by Viral Insertional Mutagenesis in Plasmacytoid Lymphosarcomas
- 30 November 1984
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 226 (4678), 1077-1080
- https://doi.org/10.1126/science.6093260
Abstract
Rearrangement in the c-myb locus of each of four independently derived BALB/c plasmacytoid lymphosarcoma (ABPL's) is due to the insertion of a defective Moloney murine leukemia virus (M-MuLV) into a 1.5-kilobase-pair stretch of cellular DNA at the 5' end of the v-myb-related sequences. This retroviral insertion is associated with abnormal transcription of myb sequences and probably represents a step in the neoplastic transformation of ABPL cells.Keywords
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