Memory enhancement induced by hypothalamic/fornix deep brain stimulation
- 29 January 2008
- journal article
- case report
- Published by Wiley in Annals of Neurology
- Vol. 63 (1), 119-123
- https://doi.org/10.1002/ana.21295
Abstract
Bilateral hypothalamic deep brain stimulation was performed to treat a patient with morbid obesity. We observed, quite unexpectedly, that stimulation evoked detailed autobiographical memories. Associative memory tasks conducted in a double‐blinded “on” versus “off” manner demonstrated that stimulation increased recollection but not familiarity‐based recognition, indicating a functional engagement of the hippocampus. Electroencephalographic source localization showed that hypothalamic deep brain stimulation drove activity in mesial temporal lobe structures. This shows that hypothalamic stimulation in this patient modulates limbic activity and improves certain memory functions. Ann Neurol 2008;63:119–123This publication has 17 references indexed in Scilit:
- Dissociating measures of associative memory: Evidence and theoretical implicationsJournal of Memory and Language, 2007
- The Medial Temporal Lobe and Recognition MemoryAnnual Review of Neuroscience, 2007
- Stimulation of the Posterior Hypothalamus for Medically Intractable Impulsive and Violent BehaviorStereotactic and Functional Neurosurgery, 2005
- Post-training intracranial self-stimulation facilitates a hippocampus-dependent taskBehavioural Brain Research, 2005
- Material-specific deficits in “remembering” in patients with unilateral temporal lobe epilepsy and excisionsNeuropsychologia, 2002
- The Relation between Remembering and Knowing as Bases for Recognition: Effects of Size CongruencyJournal of Memory and Language, 1995
- The effects of chronic ventromedial hypothalamic stimulation on weight gain in ratsPhysiology & Behavior, 1991
- Changes in food intake with electrical stimulation of the ventromedial hypothalamus in dogsJournal of Neurosurgery, 1984
- STEREOTAXY FOR OBESITYThe Lancet, 1974
- EPILEPSY AND THE FUNCTIONAL ANATOMY OF THE HUMAN BRAINSouthern Medical Journal, 1954