Advances in understanding the mechanisms of migraine-type photophobia
- 1 June 2011
- journal article
- headache
- Published by Ovid Technologies (Wolters Kluwer Health) in Current Opinion in Neurology
- Vol. 24 (3), 197-202
- https://doi.org/10.1097/wco.0b013e3283466c8e
Abstract
Purpose of review Historically, photophobia was studied in patients and attempts to explain the underlying mechanisms have been speculative. Efforts to understand better the neural substrate of photophobia paved a way to the development of different animal models and the publication of several articles (all in 2010) on the mechanism by which light exacerbates migraine headache. Recent findings Observations made in blind migraine patients devoid of any visual perception and blind migraine patients capable of detecting light have led to the discovery of a novel retino-thalamo-cortical pathway that carries photic signal from the retina to thalamic trigeminovascular neurons believed to play a critical role in the perception of headache intensity during migraine. Evidence for modulation of the trigeminovascular pathway by light and identification of the pathway through which photic signals converge on the nociceptive pathway that mediates migraine headache provide first set of scientific data on the mechanism by which light intensifies migraine headache. Summary The findings provide a neural substrate for migraine-type photophobia. This may lead to identification and development of molecular targets for selective prevention of photophobia during migraine.Keywords
This publication has 34 references indexed in Scilit:
- Bright light activates a trigeminal nociceptive pathwayPain, 2010
- Ocular surface-evoked Fos-like immunoreactivity is enhanced in trigeminal subnucleus caudalis by prior exposure to endotoxinNeuroscience, 2009
- Visual evoked potential latency, amplitude and habituation in migraine: A longitudinal studyClinical Neurophysiology, 2008
- Vasoactive intestinal and calcitonin gene-related peptides, tyrosine hydroxylase and nitrergic markers in the innervation of the rat central retinal arteryExperimental Eye Research, 2003
- Melanopsin and rod–cone photoreceptive systems account for all major accessory visual functions in miceNature, 2003
- Visual, Long-Latency Auditory and Brainstem Auditory Evoked Potentials in Migraine: Relation to Pattern Size, Stimulus Intensity, Sound and Light Discomfort Thresholds and Pre-Attack StateCephalalgia, 2000
- The Wavelength of Light Causing Photophobia in Migraine and Tension‐type Headache Between AttacksHeadache: The Journal of Head and Face Pain, 2000
- Light-Induced Discomfort and Pain in MigraineCephalalgia, 1997
- Headache Associated With Aseptic MeningitisHeadache: The Journal of Head and Face Pain, 1995
- The allocation of nerve fibres to the anterior eye segment and peripheral ganglia of rats. II. The sympathetic innervationBrain Research, 1989