Independent impact of gout on the risk of diabetes mellitus among women and men: a population-based, BMI-matched cohort study
- 2 October 2014
- journal article
- research article
- Published by BMJ in Annals Of The Rheumatic Diseases
- Vol. 75 (1), 91-95
- https://doi.org/10.1136/annrheumdis-2014-205827
Abstract
Objective Evidence on the potential independent impact of gout on the risk of diabetes is limited to a single study of men with a high cardiovascular risk profile. Our objective was to examine this relation in the general population, particularly among women. Methods We conducted a sex-stratified matched cohort study using data from The Health Improvement Network (THIN), an electronic medical records database representative of the UK general population. Up to five non-gout individuals were matched to each case of incident gout by year of birth, year of enrolment and body mass index (BMI). Multivariate HRs for incident diabetes were calculated after additionally adjusting for smoking, alcohol consumption, physician visits, comorbidities and medication use. Results Among 35 339 gout patients (72.4% men, mean age of 62.7 years), the incidence rates of diabetes in women and men were 10.1 and 9.5 cases per 1000 person-years, respectively, whereas the corresponding rates were 5.6 and 7.2 cases per 1000 person-years among 137 056 non-gout subjects. The BMI-matched univariate and multivariate HRs of diabetes were higher among women compared with those among men (1.71; 95% CI 1.51 to 1.93 vs 1.22; 95% CI 1.13 to 1.31) and (1.48; 95% CI 1.29 to 1.68 vs 1.15; 95% CI 1.06 to 1.24), respectively (p values for interaction Conclusions This general population-based study suggests that gout may be independently associated with an increased risk of diabetes and that the magnitude of association is significantly larger in women than in men.Keywords
This publication has 37 references indexed in Scilit:
- Antihypertensive drugs and risk of incident gout among patients with hypertension: population based case-control studyBMJ, 2012
- Gout and Type 2 diabetes have a mutual inter-dependent effect on genetic risk factors and higher incidencesRheumatology, 2011
- Risk of diabetes among patients with rheumatoid arthritis, psoriatic arthritis and psoriasisAnnals Of The Rheumatic Diseases, 2010
- Impact of diabetes against the future risk of developing goutAnnals Of The Rheumatic Diseases, 2010
- Independent impact of gout on the risk of acute myocardial infarction among elderly women: a population-based studyAnnals Of The Rheumatic Diseases, 2010
- Hypothesis: Could Excessive Fructose Intake and Uric Acid Cause Type 2 Diabetes?Endocrine Reviews, 2009
- Gout and the risk of type 2 diabetes among men with a high cardiovascular risk profileRheumatology, 2008
- Obesity, Weight Change, Hypertension, Diuretic Use, and Risk of Gout in MenArchives of Internal Medicine, 2005
- Omeprazole, other antiulcer drugs and newly diagnosed goutBritish Journal of Clinical Pharmacology, 1997
- A new method of classifying prognostic comorbidity in longitudinal studies: Development and validationJournal of Chronic Diseases, 1987