Effect of an Oat Bran Enriched Diet on the Atherogenic Lipid Profile in Patients with an Increased Coronary Heart Disease Risk
- 30 September 2003
- journal article
- research article
- Published by S. Karger AG in Annals of Nutrition and Metabolism
- Vol. 47 (6), 306-311
- https://doi.org/10.1159/000072404
Abstract
Aim: To study whether an oat bran enriched diet has a specific effect in lowering total and low-density lipoprotein cholesterols, in addition to caloric and fat restriction. Methods: We performed a randomized, controlled, parallel-group, single-centre study in which 1,994 patients from the Wehrawald Hospital (Todtmoos, Germany) were screened and 235 met the criteria male gender, hypercholesterolemia, and overweight. All patients in the Wehrawald Hospital took part in a 4-week standardized inpatient lifestyle health program consisting of dietary intervention, increased physical activity, and health education. Caloric restriction, fat modification, and oat bran supplementation were part of the nutritional regimen within the lifestyle health program. Ninety-nine patients were randomized to a fat-modified diet with caloric restriction and a daily intake of 35–50 g oat bran and 136 patients to a fat-modified, oat bran-free diet with caloric restriction. Fifty-three male overweight but normocholesterolemic subjects were selected as controls. Results: The most significant decreases in total cholesterol (–67.7 ± 37.2 mg/dl; p < 0.01), low-density lipoprotein cholesterol (–56.3 ± 35.1 mg/dl; p < 0.01), and apolipoprotein B (–42.4 ± 34.1 mg/dl; p < 0.01) were found with the combination of the fat-modified and oat bran enriched food. Conclusions: Added to a fat-modified diet, oat bran within a practical range of intake significantly reduces total cholesterol, low-density lipoprotein cholesterol, and apolipoprotein B. These beneficial effects occurred independent of covariables such as physical activity or caloric and fat restriction in the diet.Keywords
This publication has 13 references indexed in Scilit:
- Prevention of coronary heart disease in clinical practice Recommendations of the Second Joint Task Force of European and other Societies on Coronary PreventionEuropean Heart Journal, 1998
- Effects of Diet and Exercise in Men and Postmenopausal Women with Low Levels of HDL Cholesterol and High Levels of LDL CholesterolThe New England Journal of Medicine, 1998
- Oat Bran Concentrate Bread Products Improve Long-Term Control of Diabetes: A Pilot StudyJournal of the American Dietetic Association, 1996
- The Effect of Pravastatin on Coronary Events after Myocardial Infarction in Patients with Average Cholesterol LevelsThe New England Journal of Medicine, 1996
- Lipoprotein(a) in endurance athletes, power athletes, and sedentary controlsMedicine & Science in Sports & Exercise, 1996
- Prevention of Coronary Heart Disease with Pravastatin in Men with HypercholesterolemiaThe New England Journal of Medicine, 1995
- Preventing heart attack and death in patients with coronary diseaseJournal of the American College of Cardiology, 1995
- Randomised trial of cholesterol lowering in 4444 patients with coronary heart disease: the Scandinavian Simvastatin Survival Study (4S)The Lancet, 1994
- Summary of the second report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel II)JAMA, 1993
- Can lifestyle changes reverse coronary heart disease?: The Lifestyle Heart TrialThe Lancet, 1990