Inflammatory Manifestations in Chronic Granulomatous Disease (CGD)
- 12 January 2008
- journal article
- review article
- Published by Springer Science and Business Media LLC in Journal of Clinical Immunology
- Vol. 28 (S1), 67-72
- https://doi.org/10.1007/s10875-007-9160-5
Abstract
Chronic granulomatous disease (CGD) is a genetically heterogeneous disease characterized by recurrent life-threatening infections with bacteria and fungi as well as dysregulated inflammatory mechanisms. CGD is caused by defects in the NADPH oxidase, the enzyme complex responsible for generation of superoxide and other reactive oxygen species (ROS) in phagocytic cells. In this review we will focus our attention on those particular inflammatory manifestations associated with CGD, their frequencies and the underlying immunologic mechanisms favoring it occurrence.Keywords
This publication has 33 references indexed in Scilit:
- Acid aspiration-induced lung inflammation and injury are exacerbated in NADPH oxidase-deficient miceAmerican Journal of Physiology-Lung Cellular and Molecular Physiology, 2007
- Cutaneous and other lupus-like symptoms in carriers of X-linked chronic granulomatous disease: incidence and autoimmune serologyClinical and Experimental Immunology, 2007
- Successful Low Toxicity Hematopoietic Stem Cell Transplantation for High-Risk Adult Chronic Granulomatous Disease PatientsTransplantation, 2005
- T cells express a phagocyte-type NADPH oxidase that is activated after T cell receptor stimulationNature Immunology, 2004
- Development of systemic lupus erythematosus in a young child affected with chronic granulomatous disease following withdrawal of treatment with interferon-gammaRheumatology, 2003
- Colitis in chronic granulomatous diseaseArchives of Disease in Childhood, 2001
- Polyarthritis resembling juvenile rheumatoid arthritis in a girl with chronic granulomatous diseaseArthritis & Rheumatism, 1994
- Discoid lupus erythematosus-like lesions in carriers of X-linked chronic granulomatous diseaseBritish Journal of Dermatology, 1990
- Corticosteroids for chronic granulomatous diseaseThe Journal of Pediatrics, 1987
- Corticosteroids in treatment of obstructive lesions of chronic granulomatous diseaseThe Journal of Pediatrics, 1987