Imbalance in X-Chromosome Expression: Evidence for a Human X-Linked Gene Affecting Growth of Hemopoietic Cells
- 28 September 1979
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 205 (4413), 1418-1420
- https://doi.org/10.1126/science.472761
Abstract
In each of six family members who were heterozygous at the X-linked locus for glucose-6-phosphate dehydrogenase, only one or the other of the two alleles at that locus was almost exclusively expressed. The data are consistent with evidence that X-chromosome inactivation is a random process that may be followed by selection for one of the two resulting cell types on the basis of an unknown gene, which is located on the X chromosome and which can affect the rate of proliferation of hemopoietic cells in humans.Keywords
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